Italian Sub Grilled Cheese Sandwich

Featured in: Oven & Pan Combos

This Italian Sub Grilled Cheese brings together classic Italian cold cuts—salami and pepperoni—layered with creamy provolone cheese on sturdy bread, then topped with a zesty lettuce mixture made with vinegar and oregano. After buttering the bread, assemble the components and grill until golden and melty for an indulgent sandwich experience. The entire preparation takes just 20 minutes, making it ideal for quick weeknight meals or satisfying lunch cravings.

Updated on Tue, 20 Jan 2026 08:20:00 GMT
Golden-brown Italian Sub Grilled Cheese sandwich, oozing melted provolone and savory cold cuts, with a tangy lettuce topping on buttery grilled bread. Save to Pinterest
Golden-brown Italian Sub Grilled Cheese sandwich, oozing melted provolone and savory cold cuts, with a tangy lettuce topping on buttery grilled bread. | spoonmargin.com

Rainy Tuesday afternoons were made for sandwiches like this. I stumbled on the combination during a particularly chaotic week when takeout felt like too much effort but cold cuts wouldn't satisfy either. Something about that crunch of iceberg against warm, salty provolone just works. My roommate wandered into the kitchen, drawn by the smell of melting cheese and salami hitting the hot pan. Now it's the sandwich we both make when we need dinner fast but still want something that feels like a treat.

Last summer my cousin from Chicago visited and claimed this reminded her of the grinders she grew up eating, except the lettuce part was genius. We made three batches that weekend, experimenting with different meats and bread until we got the ratios just right. Now she texts me every time she tries a new variation, usually with a photo of her messy kitchen counter.

Ingredients

  • 4 slices Italian bread or sturdy white sandwich bread: Flimsy bread will turn into a soggy mess, so grab something with some backbone
  • 2 tablespoons unsalted butter, softened: Room temperature spreads evenly without tearing the bread
  • 4 slices provolone cheese: A mild melter that won't overpower the salty meats
  • 6 slices salami: Gets wonderfully crisp and frilly in the pan
  • 6 slices pepperoni: Adds that perfect spicy bite and releases just enough oil to help the grilling
  • 1 cup shredded iceberg lettuce: The crunch is non-negotiable here, and iceberg holds up better than leafy greens
  • 2 tablespoons mayonnaise: Use real mayo, not the light stuff
  • 1 tablespoon red wine vinegar: Brightens everything up
  • 1 teaspoon dried oregano: Dried works better than fresh here since it disperses evenly
  • Salt and freshly ground black pepper, to taste: The cold cuts are salty, so go light on extra salt
  • 2 tablespoons mild pepperoncini rings, drained: Optional but recommended for that little tangy kick
  • 2 tablespoons thinly sliced red onion: Adds a sharp bite that plays nicely with the meats

Instructions

Product image
Blend soups, smoothies, sauces, and baby food directly in pots for quick, smooth results.
Check price on Amazon
Make the lettuce topping first:
Toss the shredded lettuce with mayo, vinegar, oregano, salt, and pepper until everything's coated
Prep your bread:
Spread softened butter on one side of each bread slice like you mean it, covering every corner
Start building:
Lay two slices butter-side down and pile on provolone, salami, and pepperoni
Add the extras:
Scatter pepperoncini and red onion on top if you're going that route
Spread the lettuce:
Divide that tangy lettuce mixture between the two sandwiches
Close it up:
Top with the remaining bread, butter-side facing out
Get your pan hot:
Heat a skillet over medium heat and cook each sandwich for 3 to 4 minutes per side
Press gently:
Use your spatula to press down occasionally so everything melts together
Slice and serve:
Cut each sandwich diagonally and eat immediately while the cheese is still molten
Product image
Blend soups, smoothies, sauces, and baby food directly in pots for quick, smooth results.
Check price on Amazon
Two halves of an Italian Sub Grilled Cheese, featuring layers of salami and pepperoni, served on a rustic plate with a side of chips. Save to Pinterest
Two halves of an Italian Sub Grilled Cheese, featuring layers of salami and pepperoni, served on a rustic plate with a side of chips. | spoonmargin.com

My dad tried to make these once while camping, using a cast iron skillet over the fire. They turned out charred in places but somehow even better, with that smoky edge you can only get from open flames. Now he calls them his campfire special, though I suspect he mostly loves telling the story.

Bread Matters More Than You Think

I've tried this with supermarket white bread and with proper Italian loaves from the bakery. The difference is night and day. You need something that can handle the weight of all those toppings without collapsing into a sad, soggy situation.

Meat Variations I've Tested

Sometimes I swap in capicola or ham if that's what's in the fridge. Once I used only pepperoni and honestly, it was overkill on the spice front. The balance of salami and pepperoni is classic for a reason.

Serving Suggestions That Work

These sandwiches are filling enough to stand alone, but a handful of kettle chips on the side never hurt anybody. I've also served them with a simple tomato salad when I need to feel slightly virtuous about the meal.

  • Cut the sandwiches into smaller strips for party food or game day
  • Wrap them in foil and keep warm in a low oven if you're feeding a crowd
  • Double the lettuce mixture and save half for tomorrow's regular sandwiches
Product image
Cook complete meals by frying, sautéing, simmering, and boiling with easy nonstick cleanup every day.
Check price on Amazon
Close-up view of an Italian Sub Grilled Cheese, highlighting the melted cheese, vibrant shredded lettuce, and golden, crispy grilled bread crust. Save to Pinterest
Close-up view of an Italian Sub Grilled Cheese, highlighting the melted cheese, vibrant shredded lettuce, and golden, crispy grilled bread crust. | spoonmargin.com

Hope this becomes your go-to for those nights when only a hot, melty, meaty sandwich will do. There's something deeply satisfying about food that comes together in twenty minutes but tastes like you put in way more effort.

Recipe FAQs

Can I prepare the lettuce mixture ahead of time?

Yes, you can mix the lettuce with mayonnaise, vinegar, and oregano up to 2 hours ahead. Store it in an airtight container in the refrigerator to keep it fresh and crisp.

What bread works best for this sandwich?

Sturdy Italian bread or white sandwich bread holds up well to grilling. Sourdough or whole wheat are excellent alternatives for added flavor and texture variation.

How do I prevent the cheese from leaking out while cooking?

Keep the heat at medium and cook gently for 3-4 minutes per side. Pressing lightly with a spatula helps distribute heat evenly without squeezing out the filling.

Can I add vegetables beyond the lettuce topping?

Absolutely. Thin slices of tomato, roasted red peppers, or fresh basil complement the flavors beautifully. Add them before the lettuce mixture for best results.

What's the best way to serve this sandwich?

Serve immediately while the cheese is melted and the bread is warm. Pair with kettle chips, a simple tomato salad, or pickled vegetables for a complete meal.

How can I make it spicier?

Incorporate hot giardiniera, extra pepperoncini rings, or red pepper flakes into the lettuce mixture. You can also swap in spicy salami varieties for additional heat.

Italian Sub Grilled Cheese Sandwich

Melty sandwich combining Italian cold cuts, provolone, and tangy lettuce topping, grilled to golden perfection.

Prep Time
10 min
Time to Cook
10 min
Overall Time
20 min
Recipe by Zoe Murphy


Skill Level Easy

Cuisine Italian-American

Makes 2 Portions

Dietary Notes None specified

What You'll Need

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

How to Make It

Step 01

Prepare Lettuce Mixture: In a bowl, combine shredded lettuce, mayonnaise, red wine vinegar, oregano, salt, and pepper. Mix well and set aside.

Step 02

Butter the Bread: Lay out the bread slices and spread one side of each with softened butter.

Step 03

Assemble Base Layer: Place two slices buttered side down on a work surface. Top each with 2 slices provolone, 3 slices salami, and 3 slices pepperoni.

Step 04

Add Optional Toppings: Distribute pepperoncini rings and red onion slices over the meats and cheese if desired.

Step 05

Layer Lettuce Mixture: Spread the lettuce mixture evenly over the meats and cheese.

Step 06

Complete Sandwiches: Top each sandwich with remaining bread slices, buttered side up.

Step 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden and cheese is melted.

Step 08

Serve: Remove from heat, slice in half, and serve hot.

Tools Needed

  • Skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy Details

Check ingredients for allergens, and ask your doctor if you’re unsure.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs from mayonnaise
  • Contains pork from salami and pepperoni

Nutrition Details (per portion)

Provided for general reference—always check with your healthcare advisor.
  • Calorie Count: 540
  • Fat Content: 34 g
  • Carbohydrates: 35 g
  • Proteins: 24 g