Artichoke Spinach Grilled Cheese

Featured in: Oven & Pan Combos

This artichoke spinach grilled cheese combines creamy spinach-artichoke filling with a blend of mozzarella, Monterey Jack, and Parmesan cheeses, grilled to golden perfection on sourdough bread. The filling mixes soft cream cheese with fresh spinach, artichoke hearts, and warm garlic for depth and richness.

Each sandwich cooks for just 3-4 minutes per side on a skillet over medium heat, creating a crispy exterior while the cheese melts throughout. The result is an elevated comfort sandwich that's both satisfying and elegant.

Preparation takes only 15 minutes with a 10-minute cook time, making this ideal for weeknight dinners or entertaining. Serve alongside tomato soup or fresh greens for a complete meal.

Updated on Tue, 20 Jan 2026 09:33:00 GMT
Golden, crispy sourdough encasing melted cheese with artichoke hearts and spinach in this rich Artichoke Spinach Grilled Cheese.  Save to Pinterest
Golden, crispy sourdough encasing melted cheese with artichoke hearts and spinach in this rich Artichoke Spinach Grilled Cheese. | spoonmargin.com

The smell of butter melting into sourdough takes me back to rainy Sunday afternoons when comfort food wasn't just a choice, it was necessary. I stumbled on this combination by accident during a desperate attempt to use up leftover spinach and artichoke dip from a party the night before. My husband looked skeptical when I suggested sandwiching it between bread, but that first crispy bite silenced all doubt. Now it's the request I get most often when temperatures drop below fifty degrees.

Last winter, my sister came over crying after a terrible breakup, and I made these without saying much. She took one bite and actually laughed through her tears, claiming it was better than therapy. Food can't fix everything, but sometimes it's the closest thing we have. That night, we ate three sandwiches between us and talked until two in the morning.

Ingredients

  • Fresh spinach: Fresh adds texture, but frozen works in a pinch if you squeeze out every drop of water
  • Artichoke hearts: Jarred artichokes packed in water have the best flavor and texture for this filling
  • Cream cheese: Room temperature is non-negotiable for that silky smooth spreadability
  • Mozzarella and Monterey Jack: This melting duo creates the perfect balance of stretch and flavor
  • Parmesan cheese: Adds that salty, umami depth that keeps the sandwich from being one-note
  • Sourdough bread: The tang cuts through all that rich cheese and holds up beautifully to grilling
  • Garlic: Fresh minced gives you those little bursts of flavor throughout the filling
  • Red pepper flakes: Even if you think you don't like heat, trust me on this tiny amount

Instructions

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Mix the filling:
Combine all your cheeses, spinach, artichokes, and seasonings in a bowl until everything's evenly distributed and creamy throughout
Assemble the sandwiches:
Spread a generous layer of that cheesy mixture on four slices, top with another slice, and butter the outside of both sides like you mean it
Grill to perfection:
Cook in a hot skillet for about four minutes per side, pressing gently with your spatula, until the bread transforms into golden crunch and cheese starts to escape slightly
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Blend soups, smoothies, sauces, and baby food directly in pots for quick, smooth results.
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The Artichoke Spinach Grilled Cheese sandwich reveals a creamy, warm filling speckled with greens on a golden crust.  Save to Pinterest
The Artichoke Spinach Grilled Cheese sandwich reveals a creamy, warm filling speckled with greens on a golden crust. | spoonmargin.com

My daughter started requesting these for her birthday dinner instead of cake, which still feels like a strange but wonderful parenting win. Something about the combination of crunchy, creamy, and savory hits every pleasure center at once. Last week she asked if she could learn to make them herself, and that felt like passing down something more valuable than a recipe.

The Bread Matters More Than You Think

I've tried this with everything from brioche to whole wheat, and sourdough is absolutely worth seeking out. The fermentation gives it structural integrity that prevents the sandwich from becoming a sad, droopy mess. The subtle tanginess also cuts through all that rich dairy, making each bite feel balanced instead of overwhelming. If you can find a local bakery loaf that's at least a day old, even better.

Make It Your Own

Sometimes I'll add chopped sun-dried tomatoes when I want something sweeter and more intense. Fresh basil leaves slipped inside before grilling add a bright, herbal note that cuts through the richness. My neighbor swears by adding a thin layer of pesto on the bread before the cheese mixture, though that might be gilding the lily.

Serving Suggestions

These deserve something fresh and acidic alongside them to balance all that comforting richness. I've found the perfect combination is a simple arugula salad with lemon vinaigrette, which cuts through like a bright knife.

  • Classic tomato soup never fails to hit the spot alongside a grilled cheese
  • A pickle spear adds the necessary acid and crunch to round out each bite
  • These reheat surprisingly well in a 350 degree oven for about ten minutes
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Artichoke Spinach Grilled Cheese on buttery sourdough, with visible spinach and artichoke chunks beside a bowl of soup. Save to Pinterest
Artichoke Spinach Grilled Cheese on buttery sourdough, with visible spinach and artichoke chunks beside a bowl of soup. | spoonmargin.com

Hope these become your new comfort food favorite too. Sometimes the simplest combinations are the ones that stick with us longest.

Recipe FAQs

Can I prepare the filling ahead of time?

Yes, the artichoke-spinach filling can be made up to 2 days in advance and stored in an airtight container in the refrigerator. Simply assemble and cook the sandwiches when ready to serve.

What bread alternatives work best?

While sourdough provides excellent texture and flavor, whole wheat bread adds nutritional fiber, or gluten-free options accommodate dietary needs. Brioche or ciabatta also work well for a different crust texture.

How do I prevent the cheese from leaking out?

Spread the filling evenly but not too thickly, leaving a small border from the bread edges. Press gently while cooking rather than aggressively to keep filling contained. Using a spatula to flip carefully helps maintain the sandwich structure.

Can frozen spinach be used instead of fresh?

Absolutely. Use 1/2 cup frozen spinach, thawed and thoroughly drained to remove excess moisture. Excess water can make the filling watery and create soggy sandwiches.

What flavor variations can enhance this sandwich?

Sun-dried tomatoes, chopped scallions, or roasted red peppers add complexity. A pinch of nutmeg complements spinach beautifully. Caramelized onions or crispy bacon bits create additional depth and texture.

Why is the sandwich rested before serving?

Resting for 1 minute allows the cheese to set slightly, making the sandwich easier to slice cleanly without the filling spilling out. This brief pause also ensures even temperature distribution throughout.

Artichoke Spinach Grilled Cheese

Decadent grilled cheese with creamy spinach-artichoke dip filling, melted between golden crisp sourdough slices.

Prep Time
15 min
Time to Cook
10 min
Overall Time
25 min
Recipe by Zoe Murphy


Skill Level Easy

Cuisine American

Makes 4 Portions

Dietary Notes Suitable for Vegetarians

What You'll Need

Vegetables

01 1 cup fresh spinach, chopped
02 1 cup canned or jarred artichoke hearts, drained and chopped

Dairy

01 4 oz cream cheese, softened
02 1/2 cup shredded mozzarella cheese
03 1/2 cup shredded Monterey Jack or Swiss cheese
04 1/4 cup grated Parmesan cheese
05 2 tablespoons unsalted butter, softened

Bread

01 8 slices sourdough bread

Seasonings

01 1 small garlic clove, minced
02 1/4 teaspoon black pepper
03 1/8 teaspoon crushed red pepper flakes, optional
04 Pinch of salt

How to Make It

Step 01

Prepare the filling: In a mixing bowl, combine softened cream cheese, mozzarella, Monterey Jack or Swiss cheese, Parmesan, chopped spinach, drained artichoke hearts, minced garlic, black pepper, red pepper flakes, and salt. Mix until well blended and uniform.

Step 02

Assemble sandwiches: Lay out all sourdough bread slices. Spread artichoke-spinach mixture evenly onto 4 slices. Top each with a remaining bread slice to form 4 sandwiches.

Step 03

Butter the exterior: Lightly spread softened butter onto the outside of each sandwich on both sides.

Step 04

Cook to golden perfection: Heat a large skillet or griddle over medium heat. Place sandwiches in pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is fully melted.

Step 05

Rest and serve: Remove from skillet and let rest 1 minute. Slice diagonally if desired and serve warm.

Tools Needed

  • Mixing bowl
  • Spoon or spatula
  • Knife and cutting board
  • Skillet or griddle
  • Spatula for flipping

Allergy Details

Check ingredients for allergens, and ask your doctor if you’re unsure.
  • Contains dairy products including cheese and butter
  • Contains wheat from bread
  • May contain soy depending on bread and cheese brand selections
  • Verify product labels for potential cross-contamination if allergies are severe

Nutrition Details (per portion)

Provided for general reference—always check with your healthcare advisor.
  • Calorie Count: 410
  • Fat Content: 23 g
  • Carbohydrates: 38 g
  • Proteins: 15 g